YUSUF TEMEL

Dr. Öğr. Üyesi YUSUF TEMEL

Unvan : DOKTOR ÖĞRETİM ÜYESİ

Birim / Bölüm : SOLHAN SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU / TIBBİ HİZMETLER VE TEKNİKLER

Email : ytemel@bingol.edu.tr

Dahili : 3820

Oda No :


İlkokul Gazi İlkokulu, Erzurum  1990-1995
Ortaokul Şair Nefi Ortaokul, Erzurum 1995-1998
Lise Atatürk Lisesi, Erzurum 1998-2001
Lisans Atatürk Üniversitesi K.K.Eğitim Fak.Kimya Öğrt. 2003-2008
Yüksek Lisans Atatürk Üniversitesi K.K.Eğitim Fak.Kimya Öğrt. 2003-2008
Doktora Atatürk Üniversitesi Kimya A.B.D, Biyokimya B.D. 2009-2014

 

Yadımcı Doçent  2015- Halen

Kimya Öğretmenliği 2008-2014

1.Hemşirelik Biyokimya I

2.Solhan S.H.M.Y.O / Veteriner Fak Biyokimya I

3.Veteriner Fak Biyokimya II

4.Solhan S.H.M.Y.O. Tıbbi Terminolji

5.Fen Bil. Ens. Enzimlerin Etki Mekanizması.

6.Fen Bil. Ens. Lipid Metabolizması ve Biyolojik Membranlar.

7. Klinik Biyokimya

8. Davranış Bilimleri

9. Laboratuvar Güvenliği

 

1.GST enziminin bıldırcın ( Coturnix, coturnix japanica) karaciğer dokularından saflaştırılması ve karakterizasyonu.( Yüksek lisans tezi)

  1. Özgençli İ, Temel Y, Küfrevioğlu Ö.İ, Çiftçi M. Investigation in vıtro effects of some pestıcıdes on the activity of mıtochondrial thioredoxin reductase enzyme that purified from raınbow trout liver Muş Alparslan Üniversitesi̇ Fen Bilimleri Dergisi., 2013, 1 (2),109-117. Full Text (PDF)                                                                                                                                                                                      
  2. Temel Y, Özgençli İ, Küfrevioğlu Öİ, Çiftçi M. Bazı pestisitlerin hindi (Meleagris gallopavo) karaciğerinden saflaştırılan mitokondrial tiyoredoksin redüktaz enziminin aktivitesi üzerine in vitro etkilerinin incelenmesi. Muş Alparslan Üniversitesi̇ Fen Bilimleri Dergisi., 2014, 2 (2), 296-302.Full Text (PDF)                                                                                                                                                                
  3. Kocyigit U.M, Aslan O.N, Gulcin I, Temel Y, Ceylan M. Synthesis and Carbonic Anhydrase Inhibition of Novel 2‐(4‐(Aryl) thiazole‐2‐yl)‐3a, 4, 7, 7a‐tetrahydro‐1H‐4, 7‐methanoisoindole‐1, 3 (2H)‐dione Derivatives. Archiv der Pharmazie. 2016, 349 (12), 955-963. Full Text (PDF)                                                                                                                                                                                       
  4. Temel Y, KÜFREVİOĞLU Ö.İ, Ciftci M. Investigation of the effects of purification and characterization of turkey (Meleagris gallopavo) liver mitochondrial thioredoxin reductase enzyme and some metal ions on enzyme activity. Turkish Journal of Chemistry 2017, 41 (1), 48-60. Full Text (PDF)                                                                                                                                                                   
  5. Ceylan M, Kocyigit U.M, Usta N.C, Gürbüzlü B, Temel Y, Alwasel S.H, Gulcin I. Synthesis, carbonic anhydrase I and II isoenzymes inhibition properties, and antibacterial activities of novel tetralone‐based 1, 4‐benzothiazepine derivatives. Journal of Biochemical and Molecular Toxicology. 2017 31(4). e21872 Full Text (PDF)                                                                                                                              
  6. Temel Y, Kocyigit U.M. Purification of glucose‐6‐phosphate dehydrogenase from rat (Rattus norvegicus) erythrocytes and inhibition effects of some metal ions on enzyme activity. Journal of Biochemical and Molecular Toxicology. 2017. 31 (9) e21927. doi: 10.1002/jbt.21927. Full Text (PDF)                                                                                                                                                                     
  7. Temel Y, Bengü A.Ş, Akkoyun H.T, Akkoyun M.B, Çiftci M. Investigation effect of astaxanthin and aluminum chloride on enzyme activities of rat erythrocyte glucose 6-phosphate dehydrogenase and 6- phosphogluconate dehydrogenase in vivo and rat erythrocyte glucose 6-phosphate dehydrogenase in vitro. Journal of Biochemical and Molecular Toxicology 2017.31. (10)  e21954. Full Text (PDF)                                                                                                                                                                                                                                                                                                                              
  8. Kocyigit, U. M,  Taşkıran, A. Ş., Taslimi, P.  Yokuş, A., Temel, Y.,  Gulçin, İ. Inhibitory effects of oxytocin and oxytocin receptor antagonist atosiban on the activities of carbonic anhydrase and acetylcholinesterase enzymes in the liver and kidney tissues of rats. Journal of Biochemical and Molecular Toxicology 2017. 31 (11). e21972.  Full Text (PDF)                                                                           
  9. Bayındır, S.,  Ayna A., Temel Y., Çiftci M. The synthesis of new oxindoles as analogs of natural product 3,3'-bis(indolyl)oxindole and in vitro evaluation for enzyme activity of G6PD and 6PGD Turkish Journal of Chemistry (2018) 42: 332 – 345   Full Text (PDF)                                                                                                                                                                                                                             
  10. Temel Y., Bozkuş T., Karagözoğlu Y., Çiftci M., Glutatyon Redüktaz (GR) Enziminin Japon Bıldırcın (Coturnix coturnix japanica) Eritrositlerinden Saflaştırılması ve Karakterizasyonu. Iğdır Univ. J. Inst. Sci. & Tech. 7(3): 143-150, 2017 Full Text (PDF)                                                                                                                                                                                                                                         
  11.  Temel Y., Koçyigit U.M., Taysı M. Ş., Gökalp F., Gürdere M.B., Budak Y., Ceylan M., Gülçin İ., Çiftci M. Purification of glutathione S‐transferase enzyme from quail liver tissue and inhibition effects of (3aR, 4S, 7R, 7aS)‐2‐(4‐((E)‐3‐(aryl) acryloyl) phenyl)‐3a, 4, 7, 7a‐tetrahydro‐1H‐4, 7‐methanoisoindole‐1, 3 (2H)‐dione derivatives on the enzyme activity. Journal of Biochemical and Molecular Toxicology 2018. 32 (3). e22034.Full Text (PDF)                                                                                                                                                                                                                                                                                                                                                                                         
  12. Caglayan, C., Temel, Y., Kandemir, F.M., Yildirim, S., Kucukler, S., Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation, apoptosis, autophagy,..  Environmental Science and Pollution Research, 2018. 1-17  Full Text (PDF)                                                                                                                                     

  13. Bayındır, S., Temel, Y., Ayna, A., Çiftci, M. The synthesis of N-benzoylindoles as inhibitors of rat erythrocyte G6PD and 6PGD. Journal of Biochemical and Molecular Toxicology. 2018.e22193 Full Text (PDF)                                                                                                                                                                                                                                                                                                                   

  14. Akkoyun M. B., Bengü A. Ş., Temel Y., Akkoyun H. T., Ekin S., Ciftci M. The effect of astaxanthin and cadmium on rat erythrocyte G6PD, 6PGD, GR, and TrxR enzymes activities in vivo and on rat erythrocyte 6PGD enzyme activity in vitro. Journal of Biochemical and Molecular Toxicology. 2018. e22170. Full Text (PDF)                                                                                                                                  

  15. AKKOYUN H. T., BENGÜ A. Ş., ULUCAN A., AKKOYUN M.B., EKİN S., TEMEL Y., ÇİFTCİ Mehmet. Effect Of Astaxanthin On Rat Brains Against Oxidative Stress Induced By Cadmium:Biochemical, Histopathological Evaluation. Journal of the Institute of Science and Technology 8(4): 33-39, 2018 Full Text (PDF)                                                                                                          

  16. TEMEL Y, TAHER S.S.M, HAMZA M.A, SHAFEEQ I.H, Koçyigit U.M., Çiftci, M, Investigation of the Inhibition Effects of Some Metal Ions on Glutathione Reductase Enzyme From Japanese Quail (Coturnix coturnix japonica) Liver. Cumhuriyet Sci. J., Vol.39-3(2018) 679-687.Full Text (PDF)                                                                                                                                                                                

  17. Temel Y., Taysi M.Ş., The Effect of Mercury Chloride and Boric Acid on Rat Erythrocyte Enzymes. Biological Trace Element Research. Vol.191.1-6. 2019 Full Text (PDF)                                                                       

  18. Taslimi, P.  Kandemir, F.M. Demir, Y. İleritürk, M. Temel, Y.  Caglayan, C. Gulçin, İ.The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide‐induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities. Journal of Biochemical and Molecular Toxicology. 2019.e22213.Full Text (PDF)                                                                                       

  19. Temel Y., Bayındır S., ​The synthesis of thiosemicarbazone-based aza-ylides as inhibitors of rat erythrocyte G6PD. Journal of the Institute of Science and Technology 9(3): 1503-1512. 2019 Full Text (PDF)                                                                                                                                                                                                                                                                                                              

  20.  Mirza Ahmed, B., Temel,Y., Çiftci, M. Purification and characterization Glutathione S-transferase enzyme from quail (Coturnix, coturnix japonica) heart and investigation the effect of some metal ion on enzyme activity.Cumhuriyet Sci. J.,40 (4), 802-812. 2019 Full Text (PDF)                                                                                                                                                          

  21. Temel, Y., Kucukler, S., Yildirim, S., Caglayan, C.,  Kandemir, F.M.  Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis. Naunyn-Schmiedeberg's Archives of Pharmacology. 393, 325–337. 2020. Full Text (PDF)                                                                                                                   

  22. Temel, Y., Ayna, A., Shafeeq, İ.H.,Çiftci, M. In vitro effects of some antibiotics on glucose-6-phosphate dehydrogenase from rat (Rattus norvegicus) erythrocyte. Journal of Drug  and Chemical  Toxicology 43 (2), 219-223. 2020. DOI: 10.1080/01480545.2018.1481083  Full Text(PDF)                                                                                                                                                                                  

  23.  Rafat Baqi, H.,Temel Y., Çiftci, M. Purification and Characterization of 6- Phosphogluconate Dehydrogenase from Japanese Quail (Coturnix, coturnix japonica) Erythrocytes. Journal of the Institute of Science and Technology 2020. Full Text (PDF)

  24. Aybek, H., Temel, Y*, Ahmed Mirza, B., Ağca, C.A, Çiftci, M.  Deciphering of The Effect of Chemotherapeutic Agents on Human Glutathione S-Transferase Enzyme and MCF-7 Cell Line. Protein & Peptide Letters. 2020 (Accepted)

  25. Taysi, M.Ş., Temel, Y. Purification and characterization of the glutathion S-transferase enzyme from quail (Coturnix coturnix japonica) liver and the impact of some metal ions on enzyme activity. Protein & Peptide Letters. 2020 (Accepted)

  26. Temel, Y., Karaman, M. Bayındır, S.   (2020). Inhibition effect and molecular docking of rhodanines containing benzene moieties on pentose phosphate pathway enzymes, an important crossroad in tumor cell fate, Journal of Molecular Structure, Submitted.

  27.  Temel, Y., Çağlayan,C., Mirza Ahmed,  B.,  Kandemir, F.M.  Çiftci. M.  The effects of chrysin and naringin on cyclophosphamide-induced in rats: Biochemical evaluation of some enzyme activities in vivo and in vitro. 2020  Submitted.

 

 

       

           

 

   

 

A.BİLDİRİLER

1.Temel, Y. Çiftci M. Purification of 6PGD enzyme from rat erythrocytes.  2nd International Conference on Organic Electronic Material Technologies. OEMT2016 17-19 May 2016 Çanakkale/Turkey. (fulltext)

2.Ayna, A. Bayindir, Sinan. Temel, Y. Synthesıs Of 3,3′-Bısındoles And İnvestigation of The Effect On The Rat Erythrocyte 6PGD.International Engineering, Science and Education Conference, December 2016 Diyarbakır, Turkey. (Abstract)

3.Temel Y, Ayna A, Çiftci M. Some Antibiotics as Inhibitors and Activators of  Rat Erythrocyte 6PGD and G6PD. International Conference on Advances and Innovations in Engineering, Elazığ, Turkey, (Oral Presentation), S 11, 10-12th MAY 2017. [Abstract]

4.Temel, Y. Bayindir, S. Ayna, A. New amide derivatives as inhibitors of glucose 6-phosphate dehydrogenase and docking studies. International Conference on Advances and Innovations in Engineering (ICAIE), OP, p5, 10-12th MAY 2017, Elazığ, Turkey. [Abstract]

5.Ayna, A. Bayindir, S. Temel, Y. Determination of the effect of 3,3′-bisindole derivatives on rat erythrocyte 6PGD: an in vitro and in silico study. International Conference on Advances and Innovations in Engineering (ICAIE), OP, p3, 10-12th MAY 2017, Elazığ, Turkey. [Abstract]

6.Ayna, A. Bayindir S. Temel, Y. New heterocyclic compounds as inhibitors of rat erythrocytes G6PD and 6PGD and docking studies. International Conference on Advances and Innovations in Engineering (ICAIE), OP, p4, 10-12th MAY 2017, Elazığ, Turkey. [Abstract]

7.Bayindir, S. Ayna, A. Temel, Y. Design and synthesis of indole derivatives for the inhibition of G6PD and detailed in silico studies. International Conference on Advances and Innovations in Engineering (ICAIE), OP, p6, 10-12th MAY 2017, Elazığ, Turkey. [Abstract]

8.Bayindir, S. Ayna A, Temel, Y. Investigation the effects of hetero aromatic compounds on rat erythrocyte 6PGD and in silico molecular docking experiments. International Conference on Advances and Innovations in Engineering (ICAIE), OP, p7, 10-12th MAY 2017, Elazığ, Turkey. [Abstract]

9.Temel Y, Shafeeq İ.H., Çiftci M. Purıfıcatıon and characterızatıon of glucose 6-phosphate dehydrogenase from japanese quaıl erythrocytes. the 4th ınternational scientific conference current problems of bıochemıstry and cell bıology  p 91, 5-6 October, 2017.Dnipro,Ukrayna. [Abstract]

10. TemelY. , Taher S. S. M., Çiftci  M..Purification and Characterization of Glutathione Reductase from Japanese Quail (Coturnix, coturnix japonica) Liver. 8TH INTERNATIONAL ADVANCED TECHNOLOGIES SYMPOSIUM.Fırat University, Elazığ-Turkey  (IATS 2017). [Abstract].

11. TemelY. , BAQİ H.R., Çiftci  M. Purification and Characterization of 6-Phosphogluconate Dehydrogenase Enzyme from Japanese Quail Erythrocytes. 8TH INTERNATIONAL ADVANCED TECHNOLOGIES SYMPOSIUM. Fırat University, Elazığ-Turkey (IATS 2017). [Abstract].

12. Ayna, A. Khosnaw L. Temel, Y. Bayindir, S. Ciftci, M. Investigating the Effect of Benzamides on the Activity of Rat Erythrocyte GST.8TH INTERNATIONAL ADVANCED TECHNOLOGIES SYMPOSIUM. Fırat University, Elazığ-Turkey (IATS 2017). (Abstract)

13.Temel, Y., Mirza Ahmed B., Çiftci  M. Purification and Characterization GST Enzyme from Quail Heart.International Conference on Physical Chemistry and Functional Materials (PCFM’18)-June 19-21, 2018, Fırat University, Elazığ-Turkey [Abstract].

14. Temel, Y., Çiftci  M.  Bazı Antibiyotiklerin Japon Bıldırcın (Coturnix, Coturnix Japonica) Karaciğer Glutatyon S-Transferaz Enziminin Aktivitesi Üzerine Etkilerinin Araştırılması. ISPEC ULUSLARARASI MÜHENDİSLİK VE FEN BİLİMLERİ KONGRESİ 3-4 Mayıs 2019, MALATYA (Fulltext)

15. Temel, Y., Çiftci  M.  Glutatyon S-Transferaz Enziminin Tavuk Yüreğinden Saflaştırılması Ve Bazı İlaçların Enzim Aktivitesi Üzerıne Etkilerinin Araştırılması. ISPEC ULUSLARARASI MÜHENDİSLİK VE FEN BİLİMLERİ KONGRESİ 3-4 Mayıs 2019, MALATYA (Fulltext)

16. Temel, Y., Çiftci  M., Bayindir, S. Catalyst-Free Synthesis of Pharmaceutıcally Attractive Thiosemicarbazone And Investigation of Effect on GST Enzymes.ISPEC ULUSLARARASI MÜHENDİSLİK VE FEN BİLİMLERİ KONGRESİ 3-4 Mayıs 2019, MALATYA (Fulltext)

17. Temel, Y., Ayna, A.,  Bengü,  A. Ş., Esim, N., Avci, V., Polat, R., Canlı, D., Bayram, N. E. Erdoğan, İ.Y., Solmaz, R., Çiftci, M. BIOCHEMICAL PARAMETERS OF BINGÖL/TURKEY HONEY.                              7th.INTERNATIONAL CONFERENCE ON MATHEMATICS, ENGINEERING, NATURAL & MEDICAL SCIENCES June 14-16, 2019 ROME - ITALY [Abstract]

 

B.POSTERLER

1. Aslan, O.N. Ceylan, M. Gürdere, M.B. Budak, Y. Koçyiğit, M.Ü. Gülçin, İ. Temel, Y. Synhesis and carbonic anhidrase inhibition of novel 2-isoindole-4-aryl thiazole derivatives. Anatolian Conference on Synthetic Organic Chemistry. ACSOC II 21-24 March 2016 Kuşadası/ Aydın/TURKEY (poster)

2. Temel,Y. Çiftci, M., Küfrevioğlu, Ö.İ.Purification and Characterization of Turkey Liver Mitochondrial TrxR. 2 nd International Conference on Organic Electronic Material Technologies (OEMT2016) May 17-19, 2016 Çanakkale, TURKEY (poster)

3.Temel,Y. Çiftci, M., Shafeeq, İ.H. Purification and Characterization of G6PD enzyme from rat erythrocytes.2 nd International Conference on Organic Electronic Material Technologies (OEMT2016) May 17-19, 2016 Çanakkale, TURKEY (poster)

 

1.Journal of Biochemical and Molecular Toxicology.

2.Cumhuriyet Üniversitesi Fen Fakültesi Fen Bilimleri Dergisi.

3.Türk Doğa ve Fen Dergisi.

4. Journal of animal physiology and animal nutrition.

5. Bitlis Eren Üniversitesi Fen Bilimleri Dergisi

1.Tiyoredoksin redüktaz enziminin gök kuşağı alabalığı ve hindi karaciğlerinden saflaştırılması, karakterizasyonu ve bazı ilaç ve kimyasalların enzim aktivitesi üzerine in vitro etkilerinin incelenmesi Atatürk Üniversitesi Araştırma Fonu 2012/150 nolu Proje Araştırmacı (2012).(Tamamlandı).

2.Glutatyon Redüktaz (GR) enziminin Japon Bıldırcın (Coturnix coturnix japanica) Eritrositlerinden Saflaştırılması ve Karakterizasyonu BÜBAP-Proje No: 918-184/2014 Araştırmacı (2015) (Tamamlandı).

3.Ratlarda Cyclophosphamide Kaynaklı Karaciğer Ve Böbrek Hasarı Üzerine Chrysin Ve Naringin'nin Etkilerinin Araştırılması .BÜBAP-Proje No:BAP-SSHMYO.2016.00.001. Yürütücü (2018) (Tamamlandı).

4. GST enziminin japon Bıldırcın (Coturnix coturnix japanica) karaciğer dokularından saflaştırılması ve karakterizasyonu.BAP-SSHMYO.2017.00.001. Yürütücü (2018) (Tamamlandı).

5.Bingöl merkez ve ilçelerinde bal üretimi, Bingöl balında bulunan çeşitli enzimlerin analizi, bazı biyokimyasal parametrelerin ve melissapalinolojik özelliklerin belirlenmesi. PİKOM-Arı.2018.004. Yürütücü  (Devam ediyor)

1. Tübitak Kimya Olimpiyat Eğitimi (KEP-1). Ankara. 2012.

2. Tübitak Kimya Olimpiyat Eğitimi  (KEP-2). Antalya. 2013.

1. TUBİTAK  Yayın teşvik ödülü